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The main concern is delayed gastric emptying, a known effect of GLP-1 medications that slows how quickly food and liquids move from your stomach into your small intestine
Research has found that insulin inhibitors can stimulate the activity of the G2 response element in intestinal endocrine L cells through the -catenin/TCF-4 signaling pathway, thereby increasing GLP-1 production 8

Also, mazdutide, developped specifically for the Chinese market, should be available by 2027 since it just completed phase 3 last month
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