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Temperature excursions can degrade the active ingredient, potentially reducing effectiveness

We also observed that the median time to onset of GLP-1 RAs-associated acute pancreatitis was 92 (range: 03,312) days across ICSRs that provided both drug initiation and AP onset times, and 2.5 months of the case series, indicating a longer onset duration compared to other gastrointestinal adverse events triggered by GLP-1 RAs (Zhou et al., 2022)

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2A, B) led us to study the beiging process

For patients with contraindications to GLP-1 receptor agonists, numerous effective alternatives exist for managing type 2 diabetes and obesity