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It is not yet FDA approved, but Phase 3 data from the TRIUMPH-4 trial (December 2025) showed an average of 28.7% body weight loss at 68 weeks at the 12 mg dose the highest ever recorded in a pharmacological weight loss trial

Additionally, the FDA label for tirzepatide (Mounjaro, Zepbound) specifically warns that it may decrease the absorption of oral contraceptives, recommending backup contraception during initiation and dose escalation

For example, these patients A1C levels dropped between 1.4% and 1.9%, compared to a decrease of less than 1% with sitagliptin alone

For overall scale weight reduction, GLP-1 agonists have shown dramatic clinical results by regulating appetite