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And retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, has shown even greater weight loss than tirzepatide in early trials

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P =0.18), GLP-1 RA were associated with a significant reduction in the incidence of MACE compared with placebo and pioglitazone, with a non-significant trend towards reduction in DPP-4 inhibitor-controlled studies [100]

In the meantime, restricted access creates disparities in treatment availability, limits geographic expansion, and introduces frustration for healthcare providers and patients alike

26,107 Figure 2 summarises how proglucagon is processed in different tissues

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