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Some people shouldnt take it, including people with a personal or family history of medullary thyroid cancer, or people with multiple endocrine neoplasia syndrome type 2
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A recent report demonstrated that peripubertal-stressed male mice exhibit increased adiposity, which triggers diminished NAMPT protein levels in adipose tissue and decreased levels of circulating eNAMPT, contributing to lifelong reductions in sociability [86]
Among 69,221 propensity-matched patients with IBD, those who had received a GLP-1 RA had a 5-year colorectal cancer incidence of 0.2% compared with 0.42% in non-GLP-1 RA users (OR, 0.49), corresponding to a 51% reduction in odds of developing colorectal cancer
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doi:10.3390/microorganisms10122507 Bulsiewicz WJ

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