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Moderate cardiovascular activity (walking, cycling, swimming) provides important benefits during Retatrutide treatment: Enhanced insulin sensitivity: Aerobic exercise improves glucose uptake and metabolic flexibility Cardiovascular conditioning: Maintains heart health and aerobic capacity during weight loss Mental health benefits: Regular movement reduces anxiety and improves mood, particularly important during medication adjustment phases Additional caloric deficit: Can modestly accelerate fat loss when combined with resistance training Active recovery: Light cardio between resistance sessions promotes blood flow and recovery The key is moderation