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[DOI] [PubMed] [Google Scholar] 34.Dave C.V., Schneeweiss S., Kim D., Fralick M., Tong A., Patorno E

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Highlights from the ATTAIN-2 and ACHIEVE-3 trials demonstrate Orforglipron's significant therapeutic potential: Weight Reduction: In the ATTAIN-2 study (T2D & Obesity), the 36 mg dose achieved a -10.5% (-10.4 kg) body weight reduction at 52 weeks

Collectively, these findings are consistent with the development of relative GLP-1 resistance acquired in the context of aging or HFD feeding