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The change in HbA1c from baseline to week 26 was the primary endpoint

This was attenuated by an intravenous injection of exenatide [55]

doi: 10.1007/s12020-020-02588-8 [DOI] [PubMed] [Google Scholar] 42

Zepbound (tirzepatide) is used for long-term weight management in adults with obesity (with a body mass index of 30 or higher) and overweight (with a body mass index of 27 or higher) with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol

During perimenopause, your levels of estrogen and progesterone begin to naturally decline