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Results from the OUTSTAND-1 trial showed Hengrui/Kailera's HRS-7535 (KAI-7535) cut HbA1c by a highest placebo-adjusted 1.62% at 32 weeks, based on the treatment efficacy estimand.

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To determine the changes in microglial activation, IL-1 and TNF- were examined by western blotting, and the number and morphology of microglia were measured by immunofluorescence

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