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Clinical trials show pancreatitis affects fewer than 1 in 200 patients over multi-year follow-up, with most large studies finding no statistically significant increase compared to placebo after adjusting for underlying risk factors
doi: 10.2337/db22-335-OR [DOI] [Google Scholar] 113

It slows gastric emptying, keeping food in your stomach longer

Qin W, Yang J, Ni Y, Deng C, Ruan Q, Ruan J, et al

427,428,429 The compound NLY01 is particularly effective at attenuating the activity of proinflammatory microglia and preventing the transformation of astrocytes to a reactive phenotype

Both hormones have a very short half-life (the time corresponding to a loss of half of their physiological activity), of only 1-2 minutes, in particular due to their degradation by dipeptidyl peptidase-4 (DPP-4)
