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performed a metanalysis comparing the extraglycaemic effects of various antihyperglycaemic agents on the lipid profile in type 2 diabetes ( p = 0.002) ( In smaller acute metabolic studies with DPP-4 inhibitors, a reduction of the post-prandial rise in triglycerides, and apolipoprotein-B 48 was observed

Collectively, these data reveal that GLP-1(2836) requires MTP-inhibitory metabolic modulation to activate sAC-dependent cAMP production in caSMCs

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Therefore, localized delivery methods, such as intravitreal implants, nanoparticle carriers, or gene therapy aimed at retinal GLP-1R expression, are essential for maximizing therapeutic effectiveness while minimizing systemic exposure

The pathobiology of diabetic complications: a unifying mechanism