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Current evidence suggests GLP-1 receptor agonists have a neutral effect on fracture risk, though bone mineral density changes may occur indirectly through substantial weight loss

Without such a protective barrier, the epithelium can be subject to damage by the acidic fluids of the stomach lumen, resulting in ulceration of the stomach lining

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Increased activity of this pathway is related to enhanced aging and the occurrence of diseases like T2D and CVDs, whereas decreased IGF-1 signaling increases the lifespans of model organisms like worms, flies, and mice