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To determine whether there might be a relationship between weight loss medication use immediately before or during pregnancy and various maternal and neonatal outcomes, we compared the rates of preterm delivery, high birth weight, neonatal intensive care unit (NICU) admission, and diagnoses of failure to thrive or congenital heart defect for babies born to mothers prescribed phentermine or a GLP-1 medication in the 90 days before pregnancy or during the first trimester to those with no documented weight loss medication exposure during pregnancy

It is noteworthy that overall serious adverse events were higher in participants with a history of heart failure compared with those without such a history

In addition, GLP-1RAs could adjust the levels of the satiety signal in the arcuate nucleus in the hypothalamus, thereby increasing satiety and reducing caloric intake (179)

Still, these findings should be interpreted cautiously, since differences in participant characteristics and study methods can influence results

This unresolved tension means we cannot currently say with certainty that GLP-1 therapy is universally beneficial for autoimmune conditions