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Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors

By activating glucagon-like peptide-1 (GLP-1) receptors, retatrutide stimulates insulin secretion and inhibits glucagon release, leading to improved blood sugar control

JAMA 327 , 24232433 (2022)

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212214 GLP-1 RAs reverse detrimental epigenetic changes by promoting the demethylation of the GLP-1R gene, thereby restoring its expression and improving insulin sensitivity

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