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In addition, two large-scale, double-blind, placebo-controlled phase 3 clinical studies called Evoke and Evoke + are underway to investigate the disease-mitigating potential of semaglutide in patients with AD with early symptoms and to explore its effects on AD biomarkers and neuroinflammation (Cummings et al., 2025)

The only treatment that has consistently demonstrated long-term success in managing obesity is metabolic surgery, says Tyler Cohn, MD, interim director, division of minimally invasive, bariatric and community general surgery at Loyola Medicine

Clinically, this can present as an initial strong response followed by diminishing returns despite adherence and dose optimization

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2012, pp