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doi: 10.1038/nm.4257 106 KindeB.WuD

Glucose-dependent insulinotropic polypeptide receptor agonism for treating metabolic conditions was initially dismissed due to concerns that GIP receptor agonists (GIP RA) fail to stimulate insulin secretion in patients with type 2 diabetes, stimulate glucagon secretion worsening hyperglycaemia, and contribute to obesity [57]