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The ADH1B*3 variant (rs2066702) has been shown to exhibit lower activity compared to ADH1B*2
Some are approved by the US Food and Drug Administration (FDA) just for weight loss, along with healthy lifestyle changes, including a reduced-calorie diet and increased physical activity

doi: 10.3390/ijms19010026 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Armstrong MJ, Gaunt P, Aithal GP, et al

[6] Muttenthaler M, et al
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Rich, spicy, or heavily seasoned foods typically worsen nausea by stimulating gastric acid and slowing digestion further