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How Tirzepatide Works: A Dual Receptor Agonist Tirzepatide operates by activating two key metabolic receptors : GLP-1 (Glucagon-Like Peptide-1) GIP (Gastric Inhibitory Polypeptide) Both hormones play essential roles in metabolism, influencing insulin secretion, appetite suppression, and weight loss

In the context of simultaneous GLP-1 activation and caloric restriction, GIP might help mobilize fat stores more effectively or prevent metabolic adaptations that normally fight weight loss

These claims align with industry best practices for peptide quality assurance , though independent verification remains the responsibility of each researcher

The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 15 studies