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these animals display no response in glucose lowering after EX-4 treatment during IPGTTs, consistent with the established role of the GLP-1R [1], [33]

This also applies to signaling mechanisms mediated by GLP-1R

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How do GLP-1 therapies work

[DOI] [PubMed] [Google Scholar] 7.Reiner J., Berlin P., Held J., Thiery J., Skarbaliene J., Griffin J., et al

(84) showed that the PKA pathway also mediated the GLP-1-induced inhibition of ANG II signaling on cRAF (Ser 259) in glomerular endothelial cells, providing a further explanation for the renal protective effects of GLP-1