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Impact of GLP-1 agonists on male reproductive healthA narrative review

Secil Erbil Bilir, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark

Combining them wont improve results and could increase side effects like nausea, vomiting, diarrhea, or, in rare cases, pancreatitis

Among the numerous beneficial effects mediated by GLP-1R agonists are regulation of blood glucose, lowering of body weight via inhibition of food intake and the decrement of gastric motility, stimulation of cell proliferation, reduction of inflammation and apoptosis, improvement of cardiovascular function, and neuroprotection

The evidence shows that GLP-1R signaling mitigates ER stress by upregulating the major chaperone BiP (GRP78), which keeps UPR sensors inactive (Cunha et al., 2009)

Conclusions Although GLP-1s alone can produce significant weight reduction and related health benefits, several challenges limit its long-term success for individuals and populations