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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

In another huge manufacturing outlay, Eli Lilly sets aside $1.2 billion for upgrades in Puerto Rico where it will make its new oral GLP-1

Research is mixed on this low-carb diet for people with type 2 diabetes

The benefit was especially strong in women and older adults.

Lifestyle interventions represent the foundation of obesity treatment, yet an escalation to pharmacological and/or surgical interventions is often needed