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The use of gut-hormone receptors agonists as new therapeutic options for obesity and some of its related comorbidities, such as type 2 diabetes, has resulted in an unprecedented efficacy in the medical management of people living with obesity (PLWO)

Compounded GLP-1 drugs are going away Suggested Caption: The shortage of name-brand GLP-1 drugs has ended, and less expensive compounded GLP-1 drugs will no longer be available

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This review article discusses the potential antidepressant effects of GLP-1RAs, especially in the context of their action on the processes related to neuroprotection, inflammation, stress response, energy metabolism, gut-brain crosstalk and the stability of the gut microbiota