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intracellular cAMP PKA-CREB pathway G-protein-coupled receptors

Through multi-receptor agonism, Reta

Patients who achieved weight loss with GLP-1 Receptor Agonists (RAs) can sustain their results with generic anti-obesity medications, including metformin, a study presented at the 61st Annual...

Marey A

and increased insulin early AUC and C-peptide total and early AUCs

These effects were observed with central, but not peripheral, administration of the agonist and antagonist, suggesting receptor expression on the luminal, CSF-facing side of the choroid plexus, which aligned with GLP-1R-mediated modulation of luminally-expressed transporters in excised choroid plexus