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It has shown significant promise as an effective intervention against type 2 diabetes (T2D) and excessive body weight, resulting in the United States Food and Drug Administration (FDA) approving its use against both conditions in May 2022 for T2D and November 2023 for obesity

In Phase 1 studies, survodutide was generally well tolerated, with no significant safety or tolerability issues observed in either healthy individuals with overweight or obesity [87, 88]

Compounded semaglutide prepared by reputable compounding pharmacies will include semaglutide base, which is the same active ingredient used in Ozempic and Wegovy

doi: 10.3389/FENDO.2022.1033479 23 KoppKOGlotfeltyEJLiYGreigNH

[6] [23] The daily dosing may allow for more flexible dose adjustments if tolerability issues arise

Taken together, these findings suggest a possible positive interaction between estrogen status and GLP-1based therapy