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Major Adverse Cardiovascular Events among Patients with Type-2 Diabetes, a Nationwide Cohort Study Comparing Primary Metabolic and Bariatric Surgery to GLP-1 Receptor Agonist Treatment

There are differences in the efficacy and mechanisms of different GLP-1RAs in the treatment of DPN

326,327 Interestingly, one study found that GIPs ability to augment insulin actions on adipose tissue was blunted in human adipocytes from obese but not lean individuals

The GLP-1 price war continues

Daily versus weekly formulation timing The timing calculus changes completely for daily GLP-1 formulations like liraglutide

The SURPASS and SURMOUNT trials demonstrate the effectiveness of tirzepatide in improving glycaemic control and promoting weight loss in obese individuals with and without T2D, approaching levels seen from bariatric surgery