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[7] [8] A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings

Indeed, in rodent models where they lack GLP-1 receptors in the brain, the central anti-inflammatory response is essentially blocked

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Ozempic helps lower blood sugar, reduces the risk of certain heart problems, and often brings the added benefit of weight loss

Soykan I, Sarosiek I, McCallum RW

For background on the terminology, the Retatrutide Peptide overview explains why this distinction matters