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Nat Rev Nephrol (2021) 17(4):22744

Afib is a condition in which the heart beats in an uneven way (called arrhythmia)

The reduction in mean seated systolic blood pressure in the trials placebo cohort clocked in at 5.8 mmHg

All meta-analyses were conducted using a random-effects model irrespective of I value, in accordance with Cochrane Handbook recommendations

Centrally, they act on hypothalamic and brainstem nuclei to reduce appetite and increase satiety

Whilst these mechanisms are beneficial for diabetes and weight management, they create specific considerations in the perioperative setting that may necessitate temporary discontinuation