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Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

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Clinical Frameworks: Defining Obesity Beyond Body Mass Index (BMI) An important milestone of 2025 was the publication of The Lancet Diabetes & Endocrinology Commission on the Definition and Diagnostic Criteria of Clinical Obesity

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odds ratio 3.3536.97), rates of pulmonary aspiration (0.1% to 0.2%) remain quite low, with no significant increase in comparison to control groups

Only 8% of individuals (or one in 12) initiating a glucagon-like peptide-1 (GLP-1) agonist drug for obesity without diabetes continued to do so at three years, according to the latest real-world research from Prime Therapeutics (Prime)