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Consistent with our previous findings (20), oral gavage of systemically active doses of sitagliptin (10 mg/kg) inhibited plasma DPP-4 activity by approximately 85% when assessed 30 minutes after oral administration (Figure 1B)

Outcomes were similar to those who remained on GLP-1 therapy, and most participants maintained HbA1c below the diagnostic threshold for diabetes

Hartman ML, Loomba R, Lawitz EJ, et al

(2008) Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

8385 Metformin by activating AMPK blocks the alpha-dicarbonyl-mediated alteration of the apolipoprotein component leading to the mitigation of HDL dysfunction and minimizing low-density lipoprotein-induced damage

Recently, glucagon-like peptide 1 receptor agonists (GLP-1RAs), a class of drugs used to treat type 2 diabetes and obesity, have shown therapeutic effects against NAFLD