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[DOI] [PubMed] [Google Scholar] 39.Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ
With just eight airings, the ads were 452% more effective than the average pharmaceutical ad and drove 136.8 million impressions

Clinical trials show that nausea improves after 48 weeks regardless of caffeine consumption, suggesting caffeine mainly affects tolerability rather than therapeutic outcome
MACE=major adverse cardiovascular event

However, these agents can be expensive for patients whose insurances do not cover the medications

doi: 10.1016/0024-3205(85)90064-5
