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Data were normalized to maximum concentrations of GLP-1 or GIP (100%) and no ligand (0%) and analyzed by nonlinear regression (sigmoidal concentration-response) and plotted using GraphPad Prism 7 software

We constructed six unexposed control groups by propensity score matching on: (1) all confounders and (2) all confounders except BMI and pre-existing diabetes to assess the influence of the primary indications for treatment

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