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As outlined earlier, cardiometabolic diseases or risk factors such as type 2 diabetes (Nichols et al., 2004), obesity (Powell-Wiley et al., 2021) and hypertension (Oh and Cho, 2020) are major predictors for HF

These divergent findings likely reflect heterogeneity in study design, mechanisms of action of the drugs evaluated, duration of follow-up, and the degree of metabolic phenotyping across populations