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doi: 10.1016/j.tins.2017.01.002 [DOI] [PMC free article] [PubMed] [Google Scholar] 158.Flannery PJ, Trushina E

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48 GLP-1 RA injectable agents in development for obesity treatment Survodutide Studied in a phase 2 randomized, double-blind trial in persons with pre-obesity and obesity (without diabetes) for 46 weeks

The test examines genetic variants like FTO rs9939609 and MC4R rs17782313 that influence hunger, satiety, and weight gain

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Moreover, small-molecule GLP-1RAs offer a solution to the bioavailability limitations faced by oral peptide-based agents, which often depend on absorption enhancers (e.g., SNAC) and strict fasting protocols [74]