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Restless legs syndrome and quality of life in chronic hemodialysis patients

Moreover, due to its potent effect on gastrointestinal function, it can lead to delayed gastric emptying and alter intestinal motility

Clinically, GLP-1 RAs were initially approved for type 2 diabetes mellitus (T2DM) management, demonstrating durable glycemic control and cardiovascular risk reduction in trials ( [3] )

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While often temporary, these effects can sometimes lead to critical complications, that includes dehydration requiring hospital care

The titration window must also accommodate glucagon-linked effects, heart rate drift, hepatic flux, alongside the familiar incretin gastrointestinal profile, so step-ups are spaced more conservatively than a tirzepatide ladder [3]