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Acute effects of Ex-4 and GLP-1 Since Ex-4c is derived from Ex-4 and GLP-1 is an endogenous peptide agonist, we wanted to compare the effects of these peptides to those of Ex-4c

The GLP-1 and GIP receptor activation enhances insulin secretion, reduces appetite, and slows gastric emptying

3 Source: EY-Parthenon GLP-1 Consumer Survey (March 2025) 4 The impact isnt uniform across segments or occasions

Acylated GLP-1RAs, like liraglutide and semaglutide, heve limited direct BBB penetration but still reach critical areas such as the arcuate nucleus (ARH) through indirect pathways [125]

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