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While many people do remarkably well on them, a subset lose little to no weight on new GLP-1 drugsso-called because they mimic a naturally occurring hormone in the body called GLP-1 thats involved in regulating blood sugar, appetite, and digestion

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Right now, theres no clear-cut answer

This was associated with a reduction in macrophage infiltration, lower expression of IL-1 and IL-6, and an increase in IL-10 in the heart (41)

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Further analysis through KEGG pathway analysis revealed that 10 upregulated genes are involved in the melanogenesis pathway, which is related to skin pigmentation and may play a role in skin response to stress or damage (Figure 2B)