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Among the marketed large molecule injectable GLP-1 agonists, semaglutide, apart from weight-loss, is being studied for kidney disease and tirzepatide (a dual GLP-1 and GIP receptor agonist) is being evaluated for sleep apnea in Ph 3 clinical trials

![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

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AMP-activated protein kinase (AMPK) is a key enzyme broadly involved in regulating cellular metabolism, often called an energy sensor

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