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The polyethylene glycolylated mouse leptin antagonist (PEG-MLA)-treated mice exhibit increased fasting and glucose stimulated plasma insulin levels, decreased whole-body insulin sensitivity, elevated hepatic glucose production, and impaired insulin-mediated suppression of hepatic glucose production (Levi et al., The decrease of body fat stores in uncontrolled insulin-deficient diabetes results in marked reduce of plasma leptin levels (German et al., 2009)

Converting ml to IU: IU = Volume in ml x 100 Example with our 5 mg/ml solution: 0.8 ml = 80 IU on a U100 syringe 0.2 ml = 20 IU on a U100 syringe 0.5 ml = 50 IU on a U100 syringe This makes dosing much more practical and accurate