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Elastin fibres take time to reorganise

These figures come from separate trials in different populations and are not a direct head-to-head comparison

J Clin Endocrinol Metab 1992;75:1333-7.ArticlePubMed 69

Irregular dosing creates valleys in plasma concentration where appetite suppression weakens and side effects may worsen when dosing resumes

However, when the trigger for the intensification threshold was set at 8.5% instead of 8% and the intensification trigger was set to 4 years, the ICER increased to $70,581 and $65,235 per QALY respectively

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