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Therefore, this study focuses on designing semaglutide analogues with site-specific missense mutations, and aims to strengthen GLP-1R activation through enhanced GLP-1R ECD binding affinity [26], contributing to the development of next-generation GLP-1R agonists with improved efficacy and specificity

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Health Canada itself has noted that semaglutide is a complex synthetic peptide whose generic versions must demonstrate equivalence in safety, efficacy and quality without any differences that could affect those parameters -- a bar that has slowed the broader competitive field
Moreover, these results were not worsened following two-year termination of the GLP-1 receptor agonist if metformin was used as maintenance therapy [18]
