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Body composition starts shifting in ways the scale does not fully capture, fat loss outpaces lean mass loss by a ratio of roughly 3 to 1, meaning for every 4 pounds lost, about 3 are fat and 1 is lean tissue

This is where tracking waist circumference becomes more informative than the scale alone

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Comparatively, metformin typically provides an average A1C reduction of 1% to 1.5%

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Serum cytokeratin-18 in the diagnosis of non-alcoholic steatohepatitis: a meta-analysis

Defibrillators in non-ischemic cardiomyopathy treatment evaluation (DEFINITE) Investigators