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Results of the Phase 2 Trial on Retatrutide for Obesity Retatrutides safety and efficacy were evaluated in a 48-week, double-blind, randomized, placebo-controlled Phase 2 trial that enrolled 338 adults with obesity or overweight plus at least one weight-related condition

All of these register on a DXA scan as lean-mass loss, but none of them are the muscle tissue the headlines are about

The journey of GLP-1RAs began with the approval of exenatide in 2005, the first medication of its kind

This quality gap matters more than most researchers initially realize

When effort required to get the drug became more taxing, semaglutide-treated rats stopped earlier, which suggests that their motivation was lessened

This is an as-told-to essay based on a conversation with a 41-year-old doctor working in the Midwest