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UNICEF highlights that over 340 million children and adolescents aged 519 are overweight or obese, while chronic disease burden continues rising globally, encouraging development of improved long-acting and patient-friendly drug formulations to enhance treatment adherence and long-term outcomes

19,20 In the gastrointestinal tract, GLP-1RAs can activate the autonomic nervous system that regulates gastrointestinal motility to slow the movement of food from the stomach to the intestines, a process called gastric emptying

Medication can help prevent the formation of gallstones, but surgery, typically the removal of the gallbladder, is sometimes necessary

GLP-1 receptor agonist medications are designed to mimic or activate that same pathway

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Athauda D, et al

Triple agonists take this strategy further by targeting GLP-1R, GIPR, and the glucagon receptor (GCGR), aiming to regulate multiple complementary metabolic pathways