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McDonalds is the latest fast-food chain to jump on the GLP-1 train, testing new menu items to appeal to growing swaths of customers on the popular weight-loss drugs.

The first phase 3 retatrutide trial, TRIUMPH-4, top-line data announced today Retatrutide, a triple GLP-1,GIP, glucagon agonist studied in patients with obesity and osteoarthritis 28.7% weight loss at 68 weeks Reduced key cardiometabolic risk markers non-HDL cholesterol, triglycerides, and hsCRP Highest dose lowered systolic BP by 14 mmHg Reduced WOMAC pain scores by up to an average of 4.5 points (75.8%) and significantly improved measures of physical function GI side effects most common adverse event We now await 7 additional phase 3 trials in other obesity related comorbidities

Apply the patch firmly to the chosen area, pressing it in place with the palm of your hand for about 10 seconds

* Reinforce adherence to diet, exercise, and follow-up

Spotifys next frontier: Fitness content. Techcrunch.com, Tech Crunch, 27 Apr