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However, some individuals may experience initial gastrointestinal side effects when starting berberine

Several GLP-1 medications and related drugs are approved for long-term treatment of diabetes, obesity, or both

Clinical trials to test for effects of GLP-1s on a range of novel outcomes including alcohol use disorder and Alzheimers disease are already underway

Clinical data shows that patients lose an average of 5 to 8 pounds per month during the second and third months of treatment, with some experiencing even greater reductions

Proton-pump inhibitors (PPIs) or H2-receptor antagonists (like famotidine) offer pharmacological support for refractory GERD, and clinical evidence shows they are safe to combine with GLP-1 therapy

Store unreconstituted vials at -20C for long-term, or refrigerated at 2-8C for short-term use