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However, in vitro experiments, metformin did not directly inhibit DPP4 activity (Hinke et al., 2002)

NICE guideline NG28 (Type 2 diabetes in adults: management) emphasises that pharmacological interventions for type 2 diabetes should always be accompanied by lifestyle modifications, including dietary changes and increased physical activity

However, the SGLT2i group exhibited a lower rate of proliferative DR and vitreoretinal interventions

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