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Drugmaker Lilly said its experimental pill, orforglipron, produced better blood sugar and weight loss for diabetes patients results in a new head-to-head clinical trial.

Eli Lilly reported another success in a study pitting its once-daily oral GLP-1 therapy Orforglipron against a competing type 2 DM therapy, this time AstraZeneca's SGLT2I Farxiga (Dapagliflozin)

The growing prevalence of metabolic disease, CKD, and ASCVD have prompted investigation into the role of GLP-1R agonists in mitigating cardiovascular and metabolic risks, particularly within the framework of Cardiovascular-Kidney-Metabolic (CKM) Syndrome, irrespective of diabetic status