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& Study 1821 Investigators 2016 A Phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes

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Stay hydrated with electrolyte-rich beverages if nausea has led to reduced food intake or vomiting
The early role of UPR is to reduce translation to lessen the need for new protein folding, degrade unfolded proteins to minimize damage, and increase the expression of chaperone proteins to assist protein folding

Eur J Pharmacol (2011) 650(23):7037

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