glp 1 agonist guidelines GLP-1 receptor agonists Glucagon-Like Peptide-1 Receptor Agonists in

and (iii) compound 2 and LY3502970 (a small molecule agonist), all in complex with heterotrimeric Gs

### Funding Statement SDL and AC were supported by the National Science Foundation (Grant Nos.\ CAREER DMS-1944574 and DMS-2325258) ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained

Purpose of the Review Glucagon-like peptide 1 (GLP-1) receptor agonists (RA) have transformed obesity and type 2 diabetes (T2D) management

Chilean AI-led food tech startup NotCo has unveiled a botanical GLP Booster powder that uses food as a natural Ozempic alternative.

Oral GLP-1 RA are also under development and early data shows similar WL efficacy to semaglutide 2.4mg

It plays several important roles: Helping maintain healthy blood sugar levels after meals Supporting a feeling of fullness and satisfaction Regulating appetite and digestion When GLP-1 activity is healthy, it may help reduce cravings, support balanced energy, and contribute to gradual, sustainable weight management