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21, article 172, 2022, Lincoff, A

doi: 10.1016/S0140-6736(75)92375-2 48 CryerPE

The prevalence of overweight has increased dramatically in recent decades, with nearly 2 billion people who are overweight, including 650 million obese

At present, the studies of EX on non-diabetic obesity mainly include 152 cases of simple obesity (weight loss of 5.1 kg) (54), 60 cases of polycystic ovary syndrome (weight loss of 3.2-6.0 kg) (55), and 10 cases of metabolic syndrome (weight loss of 3.7 kg) (56), among which the most common adverse reaction is still vomiting

While this study did not investigate effectiveness for either medication, its safety profile warrants careful consideration

FDA-approved for three indications with multiple active-comparator trials, cardiovascular outcomes data, and extensive post-marketing surveillance